(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Base Information

Chemical Name:(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
CAS No.:1402636-13-8
Molecular Formula:C₁₅H₂₅N₃O₄S
Molecular Weight:343.447
Hs Code.:

Synonyms:(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Technology Process of (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

There total 8 articles about (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1402636-16-1
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1402636-13-8
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With ethanol; pyridinium p-toluenesulfonate; Reflux;

Reference yield:

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 1402636-13-8
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

3.1: water; lithium hydroxide / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.5 h / Inert atmosphere

4.2: 3 h / 20 °C

5.1: ethanol / pyridinium p-toluenesulfonate / Reflux

With ethanol; water; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; cesium fluoride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; dichloromethane; 1.1: Suzuki Coupling;

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-13-8
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: MCC-2 / ethanol / Resolution of racemate

2.1: caesium carbonate / tetrahydrofuran / 16 h / 50 °C

3.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

5.1: water; lithium hydroxide / methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.5 h / Inert atmosphere

6.2: 3 h / 20 °C

7.1: ethanol / pyridinium p-toluenesulfonate / Reflux

With ethanol; water; hydrogen; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3.1: Suzuki Coupling;