4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

Base Information

Chemical Name:4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt
CAS No.:1365989-55-4
Molecular Formula:C₂HF₃O₂*C₁₈H₁₁Cl₂N₇S
Molecular Weight:542.328
Hs Code.:

Synonyms:4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

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Chemical Property of 4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

There total 11 articles about 4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1365992-27-3
C₂₈H₂₇Cl₂N₇O₄S

: 76-05-1
trifluoroacetic acid

: 1365989-55-4
4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365989-55-4
4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 18 h

4.1: thionyl chloride / 18 h / Reflux

5.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

5.2: 6.5 h / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

10.1: dichloromethane / 2 h / 20 °C

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; diphenyl phosphoryl azide; sodium hydride; caesium carbonate; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;

Reference yield:

: 1258298-06-4
2,6-dichloro-4-cyanobenzoyl chloride

: 1365989-55-4
4-[4-(2-amino-6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3,5-dichloro-benzonitrile trifluoroacetate salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

1.2: 18 h

2.1: thionyl chloride / 18 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

3.2: 6.5 h / Reflux

4.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

5.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

8.1: dichloromethane / 2 h / 20 °C

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; sodium hydride; caesium carbonate; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;