methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate
CAS No.:1228587-63-0
Molecular Formula:C₂₅H₃₄N₆O₅
Molecular Weight:498.582
Hs Code.:

Synonyms:methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

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Chemical Property of methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

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Technology Process of methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

There total 3 articles about methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228587-62-9
methyl 1-((6-amino-2-(methylsulfonyl)-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

: 71-36-3
butan-1-ol

: 1228587-63-0
methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

Guidance literature:: With trifluoroacetic acid; at 100 ℃; for 1h;

Reference yield:

: 1228587-59-4
methyl 1-(3-(pyrrolidin-1-ylmethyl)benzylamino)cyclopropanecarboxylate

: 1228587-63-0
methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h

2: trifluoroacetic acid / 1 h / 100 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm400815m

Reference yield:

: 884507-42-0
3-(pyrrolidin-1′-ylmethyl)-benzaldehyde

: 1228587-63-0
methyl 1-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / methanol; dichloromethane / 2 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h

3: trifluoroacetic acid / 1 h / 100 °C

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm400815m