Technology Process of 5-chloro-2-fluoro-2-(2-bromomethylphenyl)benzophenone
There total 13 articles about 5-chloro-2-fluoro-2-(2-bromomethylphenyl)benzophenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-butyllithium / 1.) -70 deg C, 10 min, hexane/ether, 2.) RT, 40 min
2: 86 percent / chromic acid / diethyl ether / 3 h / 0 °C
3: N-bromosuccinimide, benzoyl peroxide / CCl4
With
N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; chromic acid;
In
tetrachloromethane; diethyl ether;
DOI:10.1021/jo00140a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Mg / 1.) ether, 0 deg C, 2.) THF, RT, 2 h
2: 81.1 percent / acetone / 16 h / Heating
3: 1.) n-BuLi / 1.) -70 deg C, 10 min, hexane/ether, 2.) RT, 16 h
4: HCl / dioxane / 2 h / Heating
5: N-bromosuccinimide, benzoyl peroxide / CCl4
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; magnesium;
In
1,4-dioxane; tetrachloromethane; acetone;
DOI:10.1021/jo00140a012
- Guidance literature:
-
Multi-step reaction with 8 steps
1: SOCl2 / 0.5 h / Ambient temperature
2: CH2Cl2 / 3 h / 25 °C
3: SOCl2 / 1 h / Ambient temperature
4: 1.) Mg / 1.) ether, 0 deg C, 2.) THF, RT, 2 h
5: 81.1 percent / acetone / 16 h / Heating
6: 1.) n-BuLi / 1.) -70 deg C, 10 min, hexane/ether, 2.) RT, 16 h
7: HCl / dioxane / 2 h / Heating
8: N-bromosuccinimide, benzoyl peroxide / CCl4
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; thionyl chloride; Perbenzoic acid; magnesium;
In
1,4-dioxane; tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jo00140a012
