diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

Base Information

Chemical Name:diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate
CAS No.:1239876-80-2
Molecular Formula:C₃₀H₃₈N₃O₉PS
Molecular Weight:647.686
Hs Code.:

Synonyms:diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

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Chemical Property of diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

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Technology Process of diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

There total 5 articles about diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1239876-79-9
(R)-2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl azide

: 83877-27-4
diisopropyl 4-nitrophenoxycarbonylphosphonoformate

: 1239876-80-2
diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

Guidance literature:: (R)-2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl azide; With trimethylphosphane; In dichloromethane; at 20 ℃; Inert atmosphere;

diisopropyl 4-nitrophenoxycarbonylphosphonoformate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1239876-75-5
(S)-3-(4-phenoxybenzenesulfonamido)-2-(tritylamino)propanol

: 1239876-80-2
diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / methanol; chloroform / 2.5 h / 0 °C

2.1: sodium hydrogencarbonate / water; ethyl acetate / 1.5 h / 0 - 20 °C

3.1: triphenylphosphine / toluene / 0.08 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: trimethylphosphane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; trimethylphosphane; In methanol; dichloromethane; chloroform; water; ethyl acetate; toluene; 3.1: |Mitsunobu Displacement / 3.2: |Mitsunobu Displacement / 4.1: |Staudinger Azide Reduction;
DOI:10.1002/hc.21256

Reference yield:

: 1239876-78-8
(S)-2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propanol

: 1239876-80-2
diisopropyl (R)-N-[2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl]carbamoylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / toluene / 0.08 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: trimethylphosphane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With triphenylphosphine; trimethylphosphane; In dichloromethane; toluene; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement / 2.1: |Staudinger Azide Reduction;
DOI:10.1002/hc.21256