1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea

Base Information

• Chemical Name: 1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea
• CAS No.: 123169-19-7
• Molecular Formula: C₂₆H₃₁FN₂O₅
• Molecular Weight: 470.541

Synonyms:1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea

Chemical Property of 1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea

Chemical Property:

Purity/Quality:

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Technology Process of 1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea

There total 2 articles about 1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(3-ethoxy-acryloyl)isocyanate (57796-78-8,928778-13-6) + <1S-(1α,2β,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine (110567-26-5) → 1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea (123169-19-7)

Guidance literature:

In benzene; at 5 - 20 ℃; for 1h;

DOI:10.1021/jm00163a030

Reference yield:

(3-ethoxy-acryloyl)isocyanate (57796-78-8,928778-13-6) + <1S-(1α,2α,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine (123238-61-9) → 1-((1R,2S,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea (123169-19-7)

Guidance literature:

In benzene; at 5 - 20 ℃; for 1h;

DOI:10.1021/jm00163a030

Reference yield: 90.0%

1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea (123169-19-7) → 1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione (123169-17-5)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; for 1.25h; Heating;

DOI:10.1021/jm00163a030

upstream raw materials:

(3-ethoxy-acryloyl)isocyanate

<1S-(1α,2α,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine

<1S-(1α,2β,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine

Downstream raw materials:

1-<<1R-(1α,2α,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4(1H,3H)-pyrimidinedione

1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

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