Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn

Base Information

• Chemical Name: Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn
• CAS No.: 436848-76-9
• Molecular Formula: C₉₆H₁₀₂ClN₇O₁₄Si
• Molecular Weight: 1641.44

Synonyms:Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn

Chemical Property of Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn

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Technology Process of Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn

There total 1 articles about Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

BOC-L-Leu-D-Ala-OH (374116-21-9) + 3-{amino-[4-(tert-butyl-dimethyl-silanyloxy)-3-chloro-phenyl]-acetoxy}-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(trityl-carbamoyl)-propionylamino]-N-trityl-succinamic acid benzyl ester → Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn (436848-76-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

DOI:10.1021/ja020237q

Reference yield: 91.0%

Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn (436848-76-9) → Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp]-HAsn(Trt)-OBn

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetic acid; at 0 ℃; for 0.75h;

DOI:10.1021/ja020237q

Reference yield:

Fmoc-L-Asn(Trt)-L-threo-O-[BOC-L-Leu-D-Ala-L-Chp(OTBS)]-HAsn(Trt)-OBn (436848-76-9) → (2S,3S)-2-[(S)-2-Amino-3-(trityl-carbamoyl)-propionylamino]-3-[(S)-2-[(R)-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionylamino]-2-(3-chloro-4-hydroxy-phenyl)-acetoxy]-N-trityl-succinamic acid benzyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; isopropyl alcohol; In N,N-dimethyl-formamide; at 25 ℃; for 0.166667h; sonication;

DOI:10.1021/ja0212314

upstream raw materials:

BOC-L-Leu-D-Ala-OH

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