2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole
CAS No.:1420834-74-7
Molecular Formula:C₁₅H₁₃ClFN₃O₃S₂
Molecular Weight:401.87
Hs Code.:

Synonyms:2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

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Chemical Property of 2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

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Technology Process of 2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

There total 3 articles about 2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1420834-98-5
C₁₅H₁₃ClFN₃OS₂

: 1420834-74-7
2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 5 ℃; for 0.5h;
DOI:10.1007/s00044-012-0431-1

Reference yield:

: 1198603-88-1
4-isopropyl-1,3-thiazole-2-carbohydrazide

: 1420834-74-7
2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: Alkaline conditions

2: potassium hydroxide / methanol

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 - 5 °C

With 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1007/s00044-012-0431-1

Reference yield:

: 1198603-96-1
5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole-2-thiol

: 1420834-74-7
2-(5-chloro-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 - 5 °C

With 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1007/s00044-012-0431-1