(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

Base Information

Chemical Name:(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid
CAS No.:528883-11-6
Molecular Formula:C₃₅H₄₅N₅O₇
Molecular Weight:647.772
Hs Code.:

(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

Synonyms:(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

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Chemical Property of (tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

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Technology Process of (tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

There total 12 articles about (tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 942232-11-3
C₃₆H₄₇N₅O₇

: 528883-11-6
(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 21h;
DOI:10.1021/jm070139l

Reference yield:

: 942232-53-3
((3-nitro-phenyl)-tert-butoxycarbonyl-amino)-acetic acid methyl ester

: 528883-11-6
(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / dioxane

2: 93 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

3: 76 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l

Reference yield:

: 3320-87-4
isocyanic acid (3-nitro-phenyl) ester

: 528883-11-6
(tert-butoxycarbonyl-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-amino)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / 2.5 h / Heating

2: 81 percent / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

3: 100 percent / H₂ / Pd/C / dioxane

4: 93 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

5: 76 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l