Technology Process of potassium (5R,6S)-2-(4'-hydroxyphenyl)-6-<(1R)-1-hydroxyethyl>carbapen-2-em-3-carboxylate
There total 9 articles about potassium (5R,6S)-2-(4'-hydroxyphenyl)-6-<(1R)-1-hydroxyethyl>carbapen-2-em-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium 2-ethylhexanoate; triphenylphosphine;
In
dichloromethane; ethyl acetate;
for 0.0833333h;
DOI:10.1021/jm00388a022
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 66 percent / imidazole / dimethylformamide / 4 h / 47 °C
2: 100 percent / toluene / 12 h / Heating
3: thionyl chloride, pyridine / tetrahydrofuran / 0.75 h / -40 - -20 °C
4: 6.5 g / pyridine / dimethylformamide / 2 h / 80 °C
5: triethylamine / CH2Cl2 / 1 h / 0 °C
6: 51 percent / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C
7: 69 percent / hydroquinone / xylene / 3.5 h / 130 °C
8: 25 percent / glacial acetic acid, tetra-n-butylammonium fluoride / tetrahydrofuran / 48 h / Ambient temperature
9: 30 percent / triphenylphosphine, potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium / ethyl acetate; CH2Cl2 / 0.08 h
With
pyridine; 1H-imidazole; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; tetrabutyl ammonium fluoride; potassium 2-ethylhexanoate; acetic acid; triethylamine; hydroquinone; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; xylene;
DOI:10.1021/jm00388a022
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / toluene / 12 h / Heating
2: thionyl chloride, pyridine / tetrahydrofuran / 0.75 h / -40 - -20 °C
3: 6.5 g / pyridine / dimethylformamide / 2 h / 80 °C
4: triethylamine / CH2Cl2 / 1 h / 0 °C
5: 51 percent / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C
6: 69 percent / hydroquinone / xylene / 3.5 h / 130 °C
7: 25 percent / glacial acetic acid, tetra-n-butylammonium fluoride / tetrahydrofuran / 48 h / Ambient temperature
8: 30 percent / triphenylphosphine, potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium / ethyl acetate; CH2Cl2 / 0.08 h
With
pyridine; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; tetrabutyl ammonium fluoride; potassium 2-ethylhexanoate; acetic acid; triethylamine; hydroquinone; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; xylene;
DOI:10.1021/jm00388a022
