4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

Base Information

Chemical Name:4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol
CAS No.:1307772-41-3
Molecular Formula:C₂₅H₂₇NO₅
Molecular Weight:421.493
Hs Code.:

Synonyms:4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

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Chemical Property of 4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

Chemical Property:

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Technology Process of 4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

There total 9 articles about 4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₄₁H₃₉NO₆

: 1307772-41-3
4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; for 0.166667h;
DOI:10.1002/chem.201002938

Reference yield:

: C₂₁H₃₁NO₆

: 1307772-41-3
4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 °C

2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

3: dichloromethane / 20 °C

4: ytterbium(III) triflate / dichloromethane / -20 - 20 °C

5: piperidine / N,N-dimethyl-formamide / 0.17 h

With piperidine; hydrogenchloride; sodium hydride; ytterbium(III) triflate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201002938

Reference yield:

: 1307770-68-8
tert-butyl (4S)-4-((R)-(2-(1,3-dioxan-2-yl)phenyl)(benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1307772-41-3
4-((1S,3S,4R)-4-(benzyloxy)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,6-dimethoxyphenol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

2: dichloromethane / 20 °C

3: ytterbium(III) triflate / dichloromethane / -20 - 20 °C

4: piperidine / N,N-dimethyl-formamide / 0.17 h

With piperidine; hydrogenchloride; ytterbium(III) triflate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002938