2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin

Base Information

• Chemical Name: 2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin
• CAS No.: 113001-92-6
• Molecular Formula: C₂₀H₁₉N₅O₆
• Molecular Weight: 425.401
• Mol file: 113001-92-6.mol

Synonyms:2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin

Chemical Property of 2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin

There total 1 articles about 2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) + acetic anhydride (108-24-7) + L-erythro-neopterin (2277-43-2) → 2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin (113001-92-6) + 2-N-acetyl-1',3'-O-benzylidene-2'-O-(α-methoxybenzyl)-L-neopterin

Guidance literature:

With pyridine; toluene-4-sulfonic acid; Yield given. Yields of byproduct given; 1.) r.t., 48 h,; 2.) 4.5 h, r.t.;

DOI:10.1002/hlca.19870700325

Reference yield: 80.0%

2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin (113001-92-6) → <3-acetamido-8-acetoxy-1,2-dihydro-1-oxopyrrolo<1,2-f>pteridin-7-yl>benzoate + 2-N-acetyl-6-<(1'S,2'S)-2'-acetoxy-3'-(benzoyloxy)-1'-bromopropyl>pterin*0.4 hexane

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; 4 A molecular sieve; barium carbonate; In tetrachloromethane; for 4.5h; Heating;

DOI:10.1002/hlca.19870700325

Reference yield:

2-N,2'-O-diacetyl-1',3'-O-benzylidene-L-neopterin (113001-92-6) → 2-N-acetyl-6-<(2'R)-2'-acetoxy-3'-(benzyloxy)zropyl>pterin

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / BaCO₃, 4 Angstroem molecular sieves, benzoyl peroxide, N-bromosuccinimide / CCl₄ / 4.5 h / Heating

2: 24 percent / hydrogen / 5 percent Pd/C / dioxane / 5 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; 4 A molecular sieve; hydrogen; barium carbonate; palladium on activated charcoal; In 1,4-dioxane; tetrachloromethane;

DOI:10.1002/hlca.19870700325

upstream raw materials:

benzaldehyde dimethyl acetal

acetic anhydride

L-erythro-neopterin