1-(4-Tolyl)piperidin-4-ol

Base Information

Chemical Name:1-(4-Tolyl)piperidin-4-ol
CAS No.:119836-09-8
Molecular Formula:C₁₂H₁₇NO
Molecular Weight:191.273
Hs Code.:
DSSTox Substance ID:DTXSID201301853
Nikkaji Number:J2.453.366B

Synonyms:119836-09-8;1-(4-tolyl)piperidin-4-ol;SCHEMBL169776;DTXSID201301853;1-(4-Methylphenyl)-4-piperidinol

Suppliers and Price of 1-(4-Tolyl)piperidin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(4-Tolyl)piperidin-4-ol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:191.131014166
Heavy Atom Count:14
Complexity:167

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)N2CCC(CC2)O

Technology Process of 1-(4-Tolyl)piperidin-4-ol

There total 5 articles about 1-(4-Tolyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 72548-31-3
1,5-Dichloropentan-3-ol

: 106-49-0,12221-03-3
p-toluidine

: 119836-09-8
1-(4-tolyl)piperidin-4-ol

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h; var.: THF, LDA, -70 deg C;

Reference yield: 80.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 624-31-7
4-tolyl iodide

: 119836-09-8
1-(4-tolyl)piperidin-4-ol

Guidance literature:: With 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; copper(l) iodide; In N,N-dimethyl-formamide; at 45 ℃; for 40h;
DOI:10.1021/ja068926f

Reference yield: 45.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 106-44-5
p-cresol

: 119836-09-8
1-(4-tolyl)piperidin-4-ol

Guidance literature:: With [(η⁵-C₅(CH₃)₄^{3,5-bis(trifluoromethyl)benzene})RhCl₂]₂; sodium carbonate; In n-heptane; at 140 ℃; for 36h; Sealed tube; Inert atmosphere; Molecular sieve;
DOI:10.1021/jacs.1c12622