(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

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Chemical Name:(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol
CAS No.:1192674-14-8
Molecular Formula:C₁₉H₂₅N₃O₄
Molecular Weight:359.425
Hs Code.:

Synonyms:(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

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Chemical Property of (R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

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Technology Process of (R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

There total 2 articles about (R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192674-09-1
(5R)-5-phenyl-4,5-dihydroisoxazole-3-carbaldehyde

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 1192674-13-7
(S)-[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-15-9
(R)-[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-14-8
(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; toluene; for 0.75h;

(5R)-5-phenyl-4,5-dihydroisoxazole-3-carbaldehyde; diastereoselective reaction; Further stages;
DOI:10.1016/j.tetasy.2009.07.025

Reference yield:

: 1192674-09-1
(5R)-5-phenyl-4,5-dihydroisoxazole-3-carbaldehyde

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 1192674-13-7
(S)-[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-15-9
(R)-[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-16-0
(S)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-14-8
(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

(5R)-5-phenyl-4,5-dihydroisoxazole-3-carbaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 6h;

With water; In tetrahydrofuran; hexane; diastereoselective reaction; aq. phosphate buffer;
DOI:10.1016/j.tetasy.2009.07.025

Reference yield: 56.0%

: 1192674-14-8
(R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol

: 1192674-19-3
(2R,3R)-2-amino-3-hydroxy-3-[(5R)-phenyl-4,5-dihydroisoxazol-3-yl]-propionic acid methyl ester

: 1192674-20-6
(2R,3R)-[(2R)-(2-amino-3-methyl)-butyrylamino]-3-hydroxy-3-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-propionic acid methyl ester

Guidance literature:: (R)-[(2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]-[(5R)-5-phenyl-4,5-dihydroisoxazol-3-yl]-methanol; With hydrogenchloride; water; In tetrahydrofuran; at 25 ℃; for 24h;

With ammonia; water; pH=8 - 10;
DOI:10.1016/j.tetasy.2009.07.025