6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Base Information

Chemical Name:6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide
CAS No.:1660148-13-9
Molecular Formula:C₁₇H₁₆F₃N₃O
Molecular Weight:335.329
Hs Code.:

Synonyms:6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

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Chemical Property of 6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

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Technology Process of 6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

There total 4 articles about 6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1660148-10-6
(E)-5-(1-hexyn-1-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

: 1660148-13-9
6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Guidance literature:: With silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.3762/bjoc.10.183

Reference yield:

: 96145-98-1
1-phenyl-3-trifluoromethyl-5-hydroxypyrazole

: 1660148-13-9
6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 4.5 h / 95 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1.5 h / 50 °C / Inert atmosphere

3: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 20 °C

4: silver trifluoromethanesulfonate / dichloromethane / 1.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine hydrochloride; sodium acetate; silver trifluoromethanesulfonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.3762/bjoc.10.183

Reference yield:

: 318288-78-7
5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde

: 1660148-13-9
6-butyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1.5 h / 50 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 20 °C

3: silver trifluoromethanesulfonate / dichloromethane / 1.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine hydrochloride; sodium acetate; silver trifluoromethanesulfonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.3762/bjoc.10.183