N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

Base Information

Chemical Name:N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid
CAS No.:864244-79-1
Molecular Formula:C₁₉H₁₉FN₄O₅
Molecular Weight:402.382
Hs Code.:

Synonyms:N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

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Chemical Property of N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

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Technology Process of N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

There total 1 articles about N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.3%

: 864244-78-0
N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid benzyl ester

: 864244-79-1
N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 1h;

Reference yield: 76.6%

: 864244-79-1
N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

: 5452-35-7
cycloheptanamine

: 864241-84-9
N-Cycloheptyl-N'-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

Reference yield: 62.1%

: 864244-79-1
N-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy}phenyl)malonic acid

: 348-54-9
2-Fluoroaniline

: 864241-81-6
N-(2-Fluorophenyl)-N'-(3-fluoro-4-{2-[(pyrrolidine-1-carbonyl)-amino]pyridin-4-yloxy}phenyl)malonamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h;