methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

Base Information

Chemical Name:methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate
CAS No.:1344997-72-3
Molecular Formula:C₂₆H₂₈ClFN₂O₄S
Molecular Weight:519.037
Hs Code.:

Synonyms:methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

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Chemical Property of methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

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Technology Process of methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

There total 7 articles about methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344997-70-1
[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]acetaldehyde

: 343238-58-4
methyl azetidine-3-carboxylate

: 1344997-72-3
methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]acetaldehyde; methyl azetidine-3-carboxylate; With sodium acetate; acetic acid; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 201849-21-0
4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

: 1344997-72-3
methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3.1: sodium acetate; bromine; acetic acid / 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

5.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere

6.1: sodium acetate; acetic acid / ethanol / 1 h / 20 °C / Inert atmosphere

6.2: 20 °C

With hydrogenchloride; potassium phosphate; water; bromine; potassium acetate; sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling / 4.1: Suzuki Coupling;

Reference yield:

: 1258440-38-8
2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazole

: 1344997-72-3
methyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-5-fluoro-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; bromine; acetic acid / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere

4.1: sodium acetate; acetic acid / ethanol / 1 h / 20 °C / Inert atmosphere

4.2: 20 °C

With hydrogenchloride; potassium phosphate; water; bromine; sodium acetate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;