2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

Base Information

Chemical Name:2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide
CAS No.:1454905-58-8
Molecular Formula:C₂₁H₂₂F₃N₅O₂
Molecular Weight:433.433
Hs Code.:

Synonyms:2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

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Chemical Property of 2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

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Technology Process of 2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

There total 7 articles about 2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₆F₃N₅O₂

: 1454905-58-8
2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

Guidance literature:: With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1454906-87-6
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazolidin-3-yl)ethanone

: 1454905-58-8
2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

2: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / 20 °C

3: N,N-dimethyl-formamide / 16 h / 75 °C

4: trifluoroacetic acid; water / dichloromethane / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1454907-07-3
2,2-difluoro-1-{(4S,5R)-4-fluoromethyl-5-[4-(6-hydroxymethylpyridin-3-yl)phenyl]-2,2-dimethyloxazolidin-3-yl}ethanone

: 1454905-58-8
2,2-difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(1-methyl-1H-imidazol-2-ylamino)methyl]pyridin-3-yl}phenyl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / 20 °C

2: N,N-dimethyl-formamide / 16 h / 75 °C

3: trifluoroacetic acid; water / dichloromethane / 2 h / 20 °C

With water; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;