(2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

Base Information

Chemical Name:(2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester
CAS No.:126402-86-6
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

Chemical Property:

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Technology Process of (2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

There total 2 articles about (2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153924-62-0
N-benzylidenephenylglycine methyl ester

: 140-88-5,9003-32-1
ethyl acrylate

: 126402-86-6
(2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

: 75516-96-0,126402-83-3
(2S,3S,5S)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid dimethyl ester

Guidance literature:: With triethylamine; triisopropoxytitanium(IV) chloride; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/S0040-4039(01)80786-3

Reference yield:

: 153924-62-0
N-benzylidenephenylglycine methyl ester

: 140-88-5,9003-32-1
ethyl acrylate

: 126402-86-6
(2R,3R,5R)-2,5-Diphenyl-pyrrolidine-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester

Guidance literature:: With triethylamine; triisopropoxytitanium(IV) chloride; Multistep reaction; 1.) r.t., 5 h;;
DOI:10.1016/S0040-4039(01)80786-3