tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate

Base Information

• Chemical Name: tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate
• CAS No.: 847579-33-3
• Molecular Formula: C₂₁H₃₃NO₅
• Molecular Weight: 379.497
• Mol file: 847579-33-3.mol

Synonyms:tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate

Chemical Property of tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate

There total 1 articles about tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-[3-(4-hydroxyphenyl)propyl]-β-alaninate (847579-32-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate (847579-33-3)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.01.029

Reference yield:

tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate (847579-33-3) + 1-Bromo-3-phenylpropane (637-59-2) → tert-butyl N-(tert-butoxycarbonyl)-N-{3-[4-(3-phenylpropoxy)phenyl]propyl}-β-alaninate (847579-34-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate (847579-33-3) + 3-(4-methylphenyl)propanol (5406-39-3) → 3-[(3-{4-[3-(4-methylphenyl)propoxy]phenyl}propyl)amino]propanoic acid hydrochloride (847585-54-0)

Guidance literature:

tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate; 3-(4-methylphenyl)propanol; With diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 48h; not specified

With hydrogenchloride; In 1,4-dioxane; at 40 ℃; for 1h;

upstream raw materials:

tert-butyl N-[3-(4-hydroxyphenyl)propyl]-β-alaninate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl N-(tert-butoxycarbonyl)-N-{3-[4-(3-phenylpropoxy)phenyl]propyl}-β-alaninate

3-[(3-{4-[3-(4-methylphenyl)propoxy]phenyl}propyl)amino]propanoic acid hydrochloride

3-[3-(4-(5-phenylpentyloxy)phenyl)propylamino]propanoic acid hydrochloride

N-{3-[4-(3-phenylpropoxy)phenyl]propyl}-β-alanine hydrochloride