EC₀₅₀

Base Information

• Chemical Name: EC₀₅₀
• CAS No.: 1402041-50-2
• Molecular Formula: C₁₉H₁₂ClF₃O₂
• Molecular Weight: 364.751
• Mol file: 1402041-50-2.mol

Synonyms:EC₀₅₀

Chemical Property of EC₀₅₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of EC₀₅₀

There total 2 articles about EC₀₅₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-chloro-2-methylnaphthalene-1,4-dione (60505-25-1) + 4-Trifluoromethylphenylacetic acid (32857-62-8) → EC050 (1402041-50-2)

Guidance literature:

With 2H₃N*H₂O₄S₂; silver nitrate; In water; acetonitrile; at 70 - 85 ℃;

DOI:10.1002/ejoc.201600144

Reference yield:

6-chloro-2-methylnaphthalen-1-ol → EC050 (1402041-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phenyliodonium diacetate derivative / water; acetonitrile / 1.5 h / -5 - 20 °C

2: silver nitrate; 2H₃N*H₂O₄S₂ / water; acetonitrile / 70 - 85 °C

With 2H₃N*H₂O₄S₂; silver nitrate; In water; acetonitrile; 2: |Kochi Cross Coupling;

DOI:10.1002/ejoc.201600144

upstream raw materials:

6-chloro-2-methylnaphthalene-1,4-dione

4-Trifluoromethylphenylacetic acid