Technology Process of 19-(benzyloxy)-19-oxojolkinolide B
There total 7 articles about 19-(benzyloxy)-19-oxojolkinolide B which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 6h;
DOI:10.1055/s-0031-1289293
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxygen / dichloromethane / 0.5 h / -78 °C / Irradiation
2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 20 °C
3: sodium hydride / tetrahydrofuran / 0 - 20 °C
4: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C
5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C
With
hydrogenchloride; dmap; water; oxygen; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
1: Wasserman oxidation;
DOI:10.1055/s-0031-1289293
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 20 °C
2: sodium hydride / tetrahydrofuran / 0 - 20 °C
3: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C
With
hydrogenchloride; dmap; water; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289293
