Technology Process of (3R,6R,8R)-2-((R)-1-Amino-2-phenyl-ethyl)-3,6,8-tribenzyl-7-hydroxy-[1,4]oxazonane-5,9-dione
There total 7 articles about (3R,6R,8R)-2-((R)-1-Amino-2-phenyl-ethyl)-3,6,8-tribenzyl-7-hydroxy-[1,4]oxazonane-5,9-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / 0 °C
1.2: 50 percent / tetrahydrofuran; diethyl ether / 24 h / 20 °C
2.1: 59 percent / PPh3; HCOOH; Et3N / Pd(OAc)2 / tetrahydrofuran / 40 h / 20 °C
3.1: 50 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl; 4-dimethylaminopyridine / CH2Cl2 / 6 h / 20 °C
4.1: 4 M HCl / ethyl acetate / 1 h / 20 °C
5.1: 8.3 mg / iPr2NEt / CH2Cl2 / 72 h / 20 °C
With
hydrogenchloride; dmap; formic acid; isopropylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)00204-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl; 4-dimethylaminopyridine / CH2Cl2 / 15 h / 20 °C
2.1: i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / 0 °C
2.2: 50 percent / tetrahydrofuran; diethyl ether / 24 h / 20 °C
3.1: 59 percent / PPh3; HCOOH; Et3N / Pd(OAc)2 / tetrahydrofuran / 40 h / 20 °C
4.1: 50 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl; 4-dimethylaminopyridine / CH2Cl2 / 6 h / 20 °C
5.1: 4 M HCl / ethyl acetate / 1 h / 20 °C
6.1: 8.3 mg / iPr2NEt / CH2Cl2 / 72 h / 20 °C
With
hydrogenchloride; dmap; formic acid; isopropylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)00204-1
