3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

Base Information

Chemical Name:3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide
CAS No.:780820-85-1
Molecular Formula:C₂₇H₃₇NO₃SSi
Molecular Weight:483.747
Hs Code.:

3-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[<i>c</i>]indene 4,4-dioxide

Synonyms:3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

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Chemical Property of 3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

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Technology Process of 3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

There total 9 articles about 3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3-(tert-butyl-diphenyl-silanyloxymethyl)-7,7,9-tris-phenylsulfanyl-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

: 780820-85-1
3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

Guidance literature:: With nickel; In ethanol; water; ethyl acetate; at 25 ℃; for 4h;
DOI:10.1016/j.tet.2006.01.111

Reference yield:

: 780820-79-3
2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methanesulfonyl-1-aza-spiro[4.5]deca-6,9-dien-8-one

: 780820-85-1
3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

Guidance literature:: 2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methanesulfonyl-1-aza-spiro[4.5]deca-6,9-dien-8-one; With potassium hexamethylsilazane; In tetrahydrofuran; at -100 - 0 ℃; for 8h;

With boron trifluoride diethyl etherate; thiophenol; In dichloromethane; at 0 - 20 ℃;

nickel; In ethanol; ethyl acetate; at 20 ℃; for 4h;
DOI:10.1002/anie.200460178

Reference yield:

: 477289-51-3
(D)-(-)-methyl homotyrosinate

: 780820-85-1
3-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-4-thia-3a-aza-cyclopenta[c]indene 4,4-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1.66 g / NEt₃ / CH₂Cl₂ / 4 h / 20 °C

2.1: 94 percent / NaBH₄ / ethanol; tetrahydrofuran / 0 - 20 °C

3.1: 90 percent / aq. NaOH / dioxane / 80 °C

4.1: PhI(OAc)2 / various solvent(s) / 0.5 h / 20 °C

5.1: 1.56 g / imidazole / dimethylformamide / 3 h / 20 °C

6.1: potassium hexamethyldisilazide / tetrahydrofuran / 8 h / -100 - 0 °C

6.2: BF₃*Et₂O; thiophenol / CH₂Cl₂ / 0 - 20 °C

6.3: 623 mg / Raney nickel / ethyl acetate; ethanol / 4 h / 20 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200460178