(1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 132302-54-6
• Molecular Formula: C₂₄H₂₅NO
• Molecular Weight: 343.469

Synonyms:(1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-3-Phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline (132283-66-0,132341-27-6) + benzylmagnesium chloride (6921-34-2) → (1R,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6) + (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Yield given;

DOI:10.1016/S0040-4020(01)87916-3

Reference yield: 78.0%

(R)-3-Phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline (132283-66-0,132341-27-6) + benzylmagnesium chloride (6921-34-2) → (1R,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6) + (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Yield given;

DOI:10.1016/S0040-4020(01)87916-3

Reference yield:

benzyl chloride (100-44-7) + 3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline (132283-66-0,132341-27-6) → (1R,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6) + (1S,1'R)-1-benzyl-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132302-54-6)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1248/cpb.39.1126

upstream raw materials:

benzyl chloride

3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline

(R)-3-Phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline

benzylmagnesium chloride

Downstream raw materials:

(1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

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