(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Base Information

Chemical Name:(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate
CAS No.:153011-61-1
Molecular Formula:C₃₀H₃₄O₅SSi
Molecular Weight:534.748
Hs Code.:

Synonyms:(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Suppliers and Price of (2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Chemical Property:

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Technology Process of (2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

There total 3 articles about (2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 116996-52-2
(2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 93-11-8
2-Naphthalenesulfonyl chloride

: 153011-61-1
(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo00079a022

Reference yield:

: 153011-60-0
Methyl (2S)-4-<(tert-butyldiphenylsilyl)oxy>-2-hydroxybutyrate

: 153011-61-1
(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BH₃*DMS, 2.) NaBH₄ / 1.) THF, room temp., 30 min, 2.) room temp., overnight

2: 86 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / 0 °C

With dmap; sodium tetrahydroborate; dimethylsulfide borane complex; triethylamine; In dichloromethane;
DOI:10.1021/jo00079a022

Reference yield:

: 153011-59-7
(5S)-<1'-<(tert-Butyldiphenylsilyl)oxy>ethyl>-2,2-cyclohexylidene-1,3-dioxolan-4-one

: 153011-61-1
(2S)-4-<(tert-Butyldiphenylsilyl)oxy>-2-hydroxybutyl 2'-naphthalenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaOMe / 0.25 h / 0 °C

2: 1.) BH₃*DMS, 2.) NaBH₄ / 1.) THF, room temp., 30 min, 2.) room temp., overnight

3: 86 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / 0 °C

With dmap; sodium tetrahydroborate; dimethylsulfide borane complex; sodium methylate; triethylamine; In dichloromethane;
DOI:10.1021/jo00079a022