1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

Base Information

Chemical Name:1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine
CAS No.:468773-50-4
Molecular Formula:C₂₄H₃₁N₃O₆S
Molecular Weight:489.593
Hs Code.:

Synonyms:1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

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Chemical Property of 1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

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Technology Process of 1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

There total 7 articles about 1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 468773-50-4
1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 5 h / 55 °C

3: 0.88 g / LAH / tetrahydrofuran / 0.5 h / 0 °C

4: 94 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.17 h / 20 °C

5: NaHCO₃; CaCl₂ / CH₂Cl₂ / 20 °C

6: toluene / 24 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; caesium carbonate; Dess-Martin periodane; triethylamine; calcium chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)00242-9

Reference yield:

: 17114-97-5
O-tert-butyl-L-serine methyl ester hydrochloride

: 468773-50-4
1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 5 h / 55 °C

3: 0.88 g / LAH / tetrahydrofuran / 0.5 h / 0 °C

4: 94 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.17 h / 20 °C

5: NaHCO₃; CaCl₂ / CH₂Cl₂ / 20 °C

6: toluene / 24 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; caesium carbonate; Dess-Martin periodane; triethylamine; calcium chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)00242-9

Reference yield:

: 468773-16-2
N-(2-nitrobenzenesulfonyl)-O-(tert-butyl)-(S)-serine methyl ester

: 468773-50-4
1-benzyl-7-tert-butoxymethyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: Cs₂CO₃ / dimethylformamide / 5 h / 55 °C

2: 0.88 g / LAH / tetrahydrofuran / 0.5 h / 0 °C

3: 94 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.17 h / 20 °C

4: NaHCO₃; CaCl₂ / CH₂Cl₂ / 20 °C

5: toluene / 24 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; caesium carbonate; Dess-Martin periodane; calcium chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)00242-9