4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

Base Information

Chemical Name:4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile
CAS No.:1202041-65-3
Molecular Formula:C₁₈H₁₄Cl₂N₄OS
Molecular Weight:405.307
Hs Code.:

Synonyms:4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

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Chemical Property of 4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

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Technology Process of 4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

There total 10 articles about 4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1202041-99-3
5-(2-bromoacetyl)-4-(2,4-dichlorophenyl)-2-morpholinothiophene-3-carbonitrile

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 1202041-65-3
4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

Guidance literature:: at 180 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 15029-32-0
4-cyanoacetylmorpholine

: 1202041-65-3
4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran; methanol / 20 h / 20 °C

5: thionyl chloride / toluene / 1 h / 80 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

7: diethyl ether / 0.25 h / 78 °C

8: bromine; acetic acid / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

9: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 0.33 h / 0 °C

10: 0.5 h / 180 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; thionyl chloride; water; bromine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1202041-94-8
4-cyano-3-(2,4-dichlorophenyl)-5-morpholin-4-ylthiophene-2-carboxylic acid chloride

: 1202041-65-3
4-(2,4-dichlorophenyl)-5-(1H-imidazol-5-yl)-2-morpholin-4-ylthiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: diethyl ether / 0.25 h / 78 °C

3: bromine; acetic acid / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

4: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 0.33 h / 0 °C

5: 0.5 h / 180 °C / Inert atmosphere; Microwave irradiation

With bromine; acetic acid; triethylamine; phosphonic acid diethyl ester; In tetrahydrofuran; diethyl ether; dichloromethane;