3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone

Base Information

• Chemical Name: 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone
• CAS No.: 610272-93-0
• Molecular Formula: C₁₇H₂₂O₂
• Molecular Weight: 258.36
• Mol file: 610272-93-0.mol

Synonyms:3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone

Chemical Property of 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone

There total 3 articles about 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

lithium acetylide-ethylenediamine complex (1216963-74-4) + 6-methyl-6-(5-methylhex-3-ynyl)-4,6,7,8-tetrahydrobenzo[1,3]dioxin-5-one (610272-92-9) → 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone (610272-93-0)

Guidance literature:

lithium acetylide-ethylenediamine complex; 6-methyl-6-(5-methylhex-3-ynyl)-4,6,7,8-tetrahydrobenzo[1,3]dioxin-5-one; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ol035322x

Reference yield:

4,6,7,8-tetrahydro-5H-benzo[d][1,3]dioxin-5-one (114908-48-4) → 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone (610272-93-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / LDA

2.1: LDA; HMPA / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 36 percent / tetrahydrofuran; hexane / 24 h / 20 °C

3.1: tetrahydrofuran / -78 - 20 °C

3.2: 65 percent / aq. HCl / tetrahydrofuran / 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/ol035322x

Reference yield:

4,6,7,8-tetrahydro-6-methyl-5H-1,3-benzodioxin-5-one (114908-67-7) → 3-ethynyl-2-hydroxymethyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone (610272-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA; HMPA / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 36 percent / tetrahydrofuran; hexane / 24 h / 20 °C

2.1: tetrahydrofuran / -78 - 20 °C

2.2: 65 percent / aq. HCl / tetrahydrofuran / 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/ol035322x

upstream raw materials:

lithium acetylide-ethylenediamine complex

6-methyl-6-(5-methylhex-3-ynyl)-4,6,7,8-tetrahydrobenzo[1,3]dioxin-5-one

4,6,7,8-tetrahydro-5H-benzo[d][1,3]dioxin-5-one

4,6,7,8-tetrahydro-6-methyl-5H-1,3-benzodioxin-5-one

Downstream raw materials:

2-(tert-butyldimethylsiloxymethyl)-3-ethynyl-4-methyl-4-(5-methylhex-3-ynyl)cyclohex-2-enone