(S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

Base Information

• Chemical Name: (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate
• CAS No.: 77443-49-3
• Molecular Formula: C₂₂H₃₄N₂O₅
• Molecular Weight: 406.522
• Mol file: 77443-49-3.mol

Synonyms:(S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

Chemical Property of (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

There total 16 articles about (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

t-Boc-L-valine (13734-41-3) + L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) → (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate (77443-49-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;

DOI:10.1248/cpb.58.680

Reference yield: 97.0%

L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) + Boc-Val-OPyCl (122751-34-2) → (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate (77443-49-3)

Guidance literature:

DOI:10.1248/cpb.39.184

Reference yield: 95.0%

t-Boc-L-valine (13734-41-3) + L-valine benzyl ester hydrochloride (2462-34-2) → (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate (77443-49-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1023/A:1016259816661

upstream raw materials:

t-Boc-L-valine

L-valine benzyl ester

tert-butyldicarbonate

Benzyl L-valyl-L-valinate hydrochloride

Downstream raw materials:

L-Valyl-L-valine benzyl ester

(3S,6S)-3,6-bis(isopropyl)piperazine-2,5-dione

Benzyl L-valyl-L-valinate hydrochloride

(N-tert-butoxycarbonyl-L-valyl)-L-valine