2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

Base Information

Chemical Name:2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate
CAS No.:135704-46-0
Molecular Formula:C₃₅H₄₃N₂O₉PSi
Molecular Weight:694.794
Hs Code.:

Synonyms:2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

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Technology Process of 2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

There total 1 articles about 2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 65109-15-1
2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytrityl-N⁶-benzoyluridin

: 135704-46-0
2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

Guidance literature:: With phosphonic Acid; pivaloyl chloride; In pyridine; at 22 ℃; for 25h;
DOI:10.1080/15257770008045452

Reference yield:

: 135704-46-0
2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)uridine 3'-hydrogen phosphonate

: C₅₉H₆₇N₈O₁₈PSi

Guidance literature:: Multi-step reaction with 2 steps

1: pivaloyl chloride / pyridine / 2 h

2: I₂ / pyridine; H₂O / 0.75 h

With iodine; pivaloyl chloride; In pyridine; water;
DOI:10.1080/15257770008045452