4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

Base Information

Chemical Name:4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine
CAS No.:1351476-73-7
Molecular Formula:C₂₆H₂₄N₄O
Molecular Weight:408.503
Hs Code.:

Synonyms:4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

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Chemical Property of 4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

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Technology Process of 4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

There total 7 articles about 4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361323-57-0
C₃₃H₃₀N₄O₃S

: 1351476-73-7
4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

Guidance literature:: With sodium hydroxide; In methanol; at 60 ℃; for 2h;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1229583-72-5
4-(3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzaldehyde

: 1351476-73-7
4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

Guidance literature:: morpholine; 4-(3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzaldehyde; With methanol; In tetrahydrofuran; dichloromethane; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1351476-73-7
4-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / acetone / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 60 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

5.1: methanol / dichloromethane; tetrahydrofuran / 0.17 h

With methanol; N-iodo-succinimide; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; acetone; acetonitrile; mineral oil;