Technology Process of ortho-[(18)F]flumazenil isopropyl ester
There total 1 articles about ortho-[(18)F]flumazenil isopropyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: oxalyl dichloride / dichloromethane / 0 °C / Inert atmosphere
2: triethylamine / 3 h / 0 - 20 °C / Inert atmosphere
3: caesium carbonate / dimethyl sulfoxide / 20 °C
4: N-Bromosuccinimide / dibenzoyl peroxide / Irradiation
5: N-ethyl-N,N-diisopropylamine / methanol / Reflux
6: 1 h / 85 °C / Microwave irradiation
7: potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA / N,N-dimethyl-formamide / 0.5 h / 130 °C
With
N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
dibenzoyl peroxide;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
