tetrabenzyl ethylidene 1,1-bisphosphonate

Base Information

• Chemical Name: tetrabenzyl ethylidene 1,1-bisphosphonate
• CAS No.: 346722-70-1
• Molecular Formula: C₃₀H₃₀O₆P₂
• Molecular Weight: 548.512
• Mol file: 346722-70-1.mol

Synonyms:tetrabenzyl ethylidene 1,1-bisphosphonate

Chemical Property of tetrabenzyl ethylidene 1,1-bisphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of tetrabenzyl ethylidene 1,1-bisphosphonate

There total 3 articles about tetrabenzyl ethylidene 1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrabenzyl 1-methoxymethyl methylene 1,1-bisphosphonate (346722-80-3) → tetrabenzyl ethylidene 1,1-bisphosphonate (346722-70-1)

Guidance literature:

With 4 A molecular sieve; toluene-4-sulfonic acid; In toluene; for 16h; Heating;

DOI:10.1081/SCC-120002004

Reference yield:

tetrabenzyl methylenediphosphonate (133918-47-5) → tetrabenzyl ethylidene 1,1-bisphosphonate (346722-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamine / 120 h / 20 °C

2: TsOH; 4 Angstroem molecular sieves / toluene / 16 h / Heating

With 4 A molecular sieve; toluene-4-sulfonic acid; diethylamine; In toluene;

DOI:10.1081/SCC-120002004

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → tetrabenzyl ethylidene 1,1-bisphosphonate (346722-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / pyridine / toluene / 0 - 20 °C

2: diethylamine / 120 h / 20 °C

3: TsOH; 4 Angstroem molecular sieves / toluene / 16 h / Heating

With pyridine; 4 A molecular sieve; toluene-4-sulfonic acid; diethylamine; In toluene;

DOI:10.1081/SCC-120002004

upstream raw materials:

tetrabenzyl 1-methoxymethyl methylene 1,1-bisphosphonate

tetrabenzyl methylenediphosphonate

benzyl alcohol

Downstream raw materials:

tetrabenzyl 2-(2,2-dimethyl-1,3-dioxane-4,6-dione)ethylene bisphosphonate

[2-(bis-benzyloxy-phosphoryl)-oxiranyl]-phosphonic acid dibenzyl ester

(R)-tert-butyl 2-(2,2-bis(bisbenzyloxyphosphoryl)ethyl)-5-methoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

C₃₇H₄₃NO₁₀P₂