Technology Process of (2E,4E,10Z)-(6S,7S)-12-(tert-Butyl-diphenyl-silanyloxy)-7-methoxy-2,6,10-trimethyl-dodeca-2,4,10-trienoic acid methyl ester
There total 9 articles about (2E,4E,10Z)-(6S,7S)-12-(tert-Butyl-diphenyl-silanyloxy)-7-methoxy-2,6,10-trimethyl-dodeca-2,4,10-trienoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
diethyl ether;
1.) -10 deg C, 20 min; 2.) -20 deg C, 30 min;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 67 percent / 1.) ozone; 2.) zinc dust, acetic acid / CH2Cl2 / 1.) -78 deg C; 2.) rt, 2 h
2: 94 percent / lanthanum chloride hydrate / methanol / 4 h
3: 98 percent / potassium carbonate / methanol / 15 h
4: 98 percent / imidazole / tetrahydrofuran / 1 h
5: 69 percent / p-toluenesulfonic acid / acetone; H2O
6: 1.) di-n-butylboron triflate, triethylamine; 2.) trimethylaluminum / 1.) CH2Cl2, -78 deg C, 3 h; 2.) CH2Cl2, toluene, -15 deg C; rt, 12 h
7: 94 percent / sodium hydride / tetrahydrofuran; hexane; dimethylformamide / 3 h / 0 °C
8: 99 percent / DIBALH / tetrahydrofuran / 1 h / -90 °C
9: 94 percent / 1.) n-butyllithium / diethyl ether / 1.) -10 deg C, 20 min; 2.) -20 deg C, 30 min
With
1H-imidazole; lanthanum(III) chloride; n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; acetic acid; triethylamine; zinc;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / lanthanum chloride hydrate / methanol / 4 h
2: 98 percent / potassium carbonate / methanol / 15 h
3: 98 percent / imidazole / tetrahydrofuran / 1 h
4: 69 percent / p-toluenesulfonic acid / acetone; H2O
5: 1.) di-n-butylboron triflate, triethylamine; 2.) trimethylaluminum / 1.) CH2Cl2, -78 deg C, 3 h; 2.) CH2Cl2, toluene, -15 deg C; rt, 12 h
6: 94 percent / sodium hydride / tetrahydrofuran; hexane; dimethylformamide / 3 h / 0 °C
7: 99 percent / DIBALH / tetrahydrofuran / 1 h / -90 °C
8: 94 percent / 1.) n-butyllithium / diethyl ether / 1.) -10 deg C, 20 min; 2.) -20 deg C, 30 min
With
1H-imidazole; lanthanum(III) chloride; n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone;
