N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1263865-07-1
• Molecular Formula: C₂₄H₂₂ClFN₆O
• Molecular Weight: 464.93

Synonyms:N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 3 articles about N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.4%

4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine (1235491-93-6) + 2-chloro-7-(4-fluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1263868-52-5) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-07-1)

Guidance literature:

In tetrahydrofuran; acetic acid; at 80 ℃;

Reference yield:

2-chloro-5-nitroanisole (1009-36-5) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 20 h / 80 °C

2.1: iron; acetic acid / ethanol / 0.5 h / 100 °C

2.2: 20 °C / Cooling

3.1: tetrahydrofuran; acetic acid / 80 °C

With iron; acetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide;

Reference yield:

4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole (1235491-92-5) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1263865-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; acetic acid / ethanol / 0.5 h / 100 °C

1.2: 20 °C / Cooling

2.1: tetrahydrofuran; acetic acid / 80 °C

With iron; acetic acid; In tetrahydrofuran; ethanol; acetic acid;

upstream raw materials:

2-chloro-5-nitroanisole

4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole

4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine

2-chloro-7-(4-fluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Downstream raw materials:

(R)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

(S)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

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