(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

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Chemical Name:(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal
CAS No.:860651-99-6
Molecular Formula:C₃₈H₅₀O₈
Molecular Weight:634.81
Hs Code.:

(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

Synonyms:(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

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Chemical Property of (S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

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Technology Process of (S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

There total 22 articles about (S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 860652-03-5
(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dien-1-ol

: 860651-99-6
(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 1.7h;
DOI:10.1002/anie.200500564

Reference yield:

: 1-(((E)-4-(4-methoxybenzyloxy)but-2-enyloxy)methyl)-4-methoxybenzene

: 860651-99-6
(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

Guidance literature:: Multi-step reaction with 13 steps

1: AD-mix-α; H2O / 2-methyl-propan-2-ol / 0 - 20 °C

2: 1.44 g / sodium periodate/SiO₂ / CH₂Cl₂ / 0.5 h

3: 6-bis[(4R)-4-phenyl-2-oxazolin-2-yl]pyridine; CuCl₂; AgSbF₆ / CH₂Cl₂ / 4 h / -78 °C

4: 89 percent / imidazole / dimethylformamide / 18 h

5: 80 percent / LiAlH₄ / diethyl ether / 1 h

6: 438 mg / TMSOTf / CH₂Cl₂ / 0.75 h / -78 °C

7: CeCl₃ / diethyl ether; tetrahydrofuran / 18 h / -78 - 20 °C

8: 239 mg / pyridinium triflate; MgSO₄ / CH₂Cl₂ / 1.5 h

9: (n-Bu)3P / tetrahydrofuran / 3 h / 20 °C

10: 0.266 g / aq. H₂O₂; pyridine / CH₂Cl₂ / 1 h / -30 °C

11: 4-dimethylaminopyridine; (i-Pr)2NEt / CH₂Cl₂ / 6 h

12: 102 mg / HF*pyridine; pyridine / tetrahydrofuran / 0 - 20 °C

13: 87 percent / TEMPO; bis(acetoxy)iodobenzene / CH₂Cl₂ / 1.7 h / 20 °C

With pyridine; 1H-imidazole; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium periodate; AD-mix-α; silver hexafluoroantimonate; lithium aluminium tetrahydride; cerium(III) chloride; tributylphosphine; trimethylsilyl trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; water; dihydrogen peroxide; pyridinium triflate; silica gel; magnesium sulfate; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; 2,6-bis[(4R)-5,5-dihydro-4-phenyl-2-oxazolyl]pyridine; copper dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/anie.200500564

Reference yield:

: 860651-93-0
(2E,5Z)-7-(tert-butyldiphenylsilanyloxy)-5-methylhepta-2,5-dienal

: 860651-99-6
(S,2Z,6E)-5-((4-methoxybenzyloxy)methoxy)-8-((2R,6R)-6-((R,E)-5-(4-methoxybenzyloxy)-4-hydroxy-2-methylpent-1-enyl)tetrahydro-4-methylene-2H-pyran-2-yl)-3-methylocta-2,6-dienal

Guidance literature:: Multi-step reaction with 12 steps

1: SiCl₄; chiral Denmark's bisphosphoramide catalyst / CH₂Cl₂ / 18 h / -78 °C

2: 1 h / Heating

3: diethylmethoxyborane; NaBH₄ / tetrahydrofuran / 18 h / -78 °C

4: imidazole; 4-dimethylaminopyridine / dimethylformamide / 18 h

5: 438 mg / TMSOTf / CH₂Cl₂ / 0.75 h / -78 °C

6: CeCl₃ / diethyl ether; tetrahydrofuran / 18 h / -78 - 20 °C

7: 239 mg / pyridinium triflate; MgSO₄ / CH₂Cl₂ / 1.5 h

8: (n-Bu)3P / tetrahydrofuran / 3 h / 20 °C

9: 0.266 g / aq. H₂O₂; pyridine / CH₂Cl₂ / 1 h / -30 °C

10: 4-dimethylaminopyridine; (i-Pr)2NEt / CH₂Cl₂ / 6 h

11: 102 mg / HF*pyridine; pyridine / tetrahydrofuran / 0 - 20 °C

12: 87 percent / TEMPO; bis(acetoxy)iodobenzene / CH₂Cl₂ / 1.7 h / 20 °C

With pyridine; 1H-imidazole; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; cerium(III) chloride; tetrachlorosilane; tributylphosphine; trimethylsilyl trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; chiral Denmark's bisphosphoramide catalyst; diethyl methoxy borane; dihydrogen peroxide; pyridinium triflate; magnesium sulfate; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200500564