benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

Base Information

Chemical Name:benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine
CAS No.:1446002-24-9
Molecular Formula:C₂₃H₂₅N₃O₃S
Molecular Weight:423.536
Hs Code.:

Synonyms:benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

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Chemical Property of benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

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Technology Process of benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

There total 5 articles about benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1446002-23-8
6-bromo-4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazine

: 100-46-9
benzylamine

: 1446002-24-9
benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; ruphos; In 1,4-dioxane; at 80 ℃; for 0.5h;

Reference yield:

: 1154740-47-2
6-bromo-5-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one

: 1446002-24-9
benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 42 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / toluene / 42 h / 100 °C

3: sodium t-butanolate; ruphos; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 0.5 h / 80 °C

With borane-THF; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; toluene; 2: |Buchwald-Hartwig Coupling / 3: |Buchwald-Hartwig Coupling;

Reference yield:

: 1154740-48-3
6-bromo-5-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 1446002-24-9
benzyl-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / toluene / 42 h / 100 °C

2: sodium t-butanolate; ruphos; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 0.5 h / 80 °C

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; ruphos; In 1,4-dioxane; toluene; 1: |Buchwald-Hartwig Coupling / 2: |Buchwald-Hartwig Coupling;