1-cyclohexylethanamine hydrochloride (1:1)

Base Information

• Chemical Name: 1-cyclohexylethanamine hydrochloride (1:1)
• CAS No.: 27586-72-7
• Molecular Formula: C8H17 N . Cl H
• Molecular Weight: 163.691
• Mol file: 27586-72-7.mol

Synonyms:Cyclohexanemethanamine,a-methyl-, hydrochloride (9CI);Cyclohexanemethylamine, a-methyl-, hydrochloride (6CI,8CI); 1-Cyclohexylethylamine hydrochloride;NSC 25106

Chemical Property of 1-cyclohexylethanamine hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 1.2mmHg at 25°C
• Boiling Point: 174.6°C at 760 mmHg
• Flash Point: 52.2°C

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-cyclohexylethanamine hydrochloride (1:1)

There total 9 articles about 1-cyclohexylethanamine hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-N-benzyl-α-cyclohexylethylamine (141396-54-5) → (S)-1-cyclohexylethylamine hydrochloride (27586-72-7)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jo960047w

Reference yield: 91.0%

(S)-(-)-α-methylbenzylamine hydrochloride (17279-30-0) → (S)-1-cyclohexylethylamine hydrochloride (27586-72-7)

Guidance literature:

With hydrogen; In water; at 100 ℃; for 3h; under 15001.5 Torr; chemoselective reaction;

DOI:10.1039/c6cy00899b

Reference yield:

C8H15N*ClH (1164111-53-8) → (R)-1-cyclohexylethan-1-amine hydrochloride (404336-48-7) + (S)-1-cyclohexylethylamine hydrochloride (27586-72-7)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; hydrogen; In methanol; dichloromethane; at 20 ℃; for 20h; under 7600.51 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja903319r

upstream raw materials:

(S)-N-benzyl-α-cyclohexylethylamine

(2S,4aS,7R,8aR)-3-Benzyl-2-cyclohexyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazine

cyclohexanecarbaldehyde

C₈H₁₅N*ClH