(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

Base Information

Chemical Name:(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide
CAS No.:1355952-59-8
Molecular Formula:C₂₆H₂₉NO₁₁S
Molecular Weight:563.582
Hs Code.:

Synonyms:(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

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Chemical Property of (4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

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Technology Process of (4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

There total 1 articles about (4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1032661-40-7
(2R,3S,4R)-2-sulfamoyloxymethyl-3,4-dihydro-2H-pyran-3,4-diyldibenzoate

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 1355952-59-8
(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

Guidance literature:: ethyl 2-bromomethyl-2-propenoate; With indium; potassium iodide; In tetrahydrofuran; for 0.25h; Reflux;

(2R,3S,4R)-2-sulfamoyloxymethyl-3,4-dihydro-2H-pyran-3,4-diyldibenzoate; With tetrakis(μ-trifluoroacetamidato)dirhodium(II); iodosylbenzene; magnesium oxide; In tetrahydrofuran; dichloromethane; at 20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201104516

Reference yield:

: 1355952-59-8
(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

: 108-24-7
acetic anhydride

: C₃₂H₃₅NO₁₄S

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.201104516

Reference yield:

: 1355952-59-8
(4R,5R,6R,7R)-7-hydroxy-4-((S)-3-(ethoxycarbonyl)-1-hydroxybut-3-enyl)-1,2,3-oxathiazocane-5,6-diyl dibenzoate-2,2-dioxide

: C₃₂H₃₇NO₁₂

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: sulfuric acid; water / tetrahydrofuran / 0 - 20 °C

With sulfuric acid; water; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201104516