tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate
CAS No.:1393901-50-2
Molecular Formula:C₃₁H₃₇F₃N₆O₃
Molecular Weight:598.668
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

There total 12 articles about tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393901-49-9
lithium 2-(2-(2-(2-((4-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-50-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1393901-50-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

3.2: 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 100 °C / Inert atmosphere; microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 18 h / 2327.23 Torr

5.2: 3 h / 2068.65 Torr

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; sodium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 130636-61-2
1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine

: 1393901-50-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

2.2: 20 °C / Cooling with ice

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 18 h / 2327.23 Torr

4.2: 3 h / 2068.65 Torr

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;