4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

Base Information

Chemical Name:4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide
CAS No.:1236265-22-7
Molecular Formula:C₂₃H₂₆N₆O
Molecular Weight:402.499
Hs Code.:

Synonyms:4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

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Chemical Property of 4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

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Technology Process of 4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

There total 6 articles about 4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236265-93-2
4-((4-chloro-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

: 1236265-22-7
4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 14099-81-1
1,2,3,4-tetrahydroisoquinoline

: 1236265-22-7
4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetonitrile; water / 0.33 h / 0 °C / pH 9 - 10

2: triethylamine / dichloromethane / 1 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.5b00138

Reference yield:

: 884195-75-9
2-(4,6-dichloro[1,3,5]triazin-2-yl)-1,2,3,4-tetrahydroisoquinoline

: 1236265-22-7
4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00138