(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

Base Information

Chemical Name:(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide
CAS No.:460352-67-4
Molecular Formula:C₂₉H₃₉NO₃
Molecular Weight:449.634
Hs Code.:

Synonyms:(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

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Chemical Property of (2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

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Technology Process of (2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

There total 5 articles about (2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460352-65-2
(1S,2R)-2-Allyloxy-1-methyl-4-phenyl-butylamine

: 460352-62-9
(2R,3S)-3-(allyloxy)-2-methyl-5-phenylpentanoic acid

: 460352-67-4
(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 23 ℃;
DOI:10.1021/jo025889b

Reference yield:

: 460352-57-2
(4R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2-methyl-5-phenylpentanoyl]-1,3-oxazolidin-2-one

: 460352-67-4
(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: triflic acid / CH₂Cl₂; cyclohexane / 0 - 20 °C

2: lithium hydroxide; H₂O₂ / H₂O; tetrahydrofuran / 3.5 h / 0 - 20 °C

3: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆^(1-); i-Pr₂NEt / acetonitrile / 23 °C

With lithium hydroxide; trifluorormethanesulfonic acid; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; cyclohexane; water; acetonitrile;
DOI:10.1021/jo025889b

Reference yield:

: 460352-60-7
(4R)-3-[(2R,3S)-3-(allyloxy)-2-methyl-5-phenylpentanoyl]-4-benzyl-1,3-oxazolidin-2-one

: 460352-67-4
(2S,3R)-3-Allyloxy-2-methyl-5-phenyl-pentanoic acid ((1S,2R)-2-allyloxy-1-methyl-4-phenyl-butyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; H₂O₂ / H₂O; tetrahydrofuran / 3.5 h / 0 - 20 °C

2: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆^(1-); i-Pr₂NEt / acetonitrile / 23 °C

With lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo025889b