3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

Base Information

Chemical Name:3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide
CAS No.:897383-41-4
Molecular Formula:C₂₃H₂₁ClN₆O₂
Molecular Weight:448.912
Hs Code.:

Synonyms:3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

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Chemical Property of 3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

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Technology Process of 3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

There total 5 articles about 3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616-79-5
2-amino-5-nitro-benzoic acid

: 897383-41-4
3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 170 °C

2: thionyl chloride; trichlorophosphate; N,N-dimethyl-formamide

3: isopropyl alcohol / Reflux

4: iron; hydrogenchloride / ethanol; water / Reflux

5: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridine / 20 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; iron; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1002/bkcs.10358

Reference yield:

: 6943-17-5
6-nitroquinazolone

: 897383-41-4
3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride; trichlorophosphate; N,N-dimethyl-formamide

2: isopropyl alcohol / Reflux

3: iron; hydrogenchloride / ethanol; water / Reflux

4: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridine / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; iron; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1002/bkcs.10358

Reference yield:

: 179688-70-1
N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine

: 897383-41-4
3-amino-N-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: iron; hydrogenchloride / ethanol; water / Reflux

2: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridine / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; hydrogenchloride; iron; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water;
DOI:10.1002/bkcs.10358