(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Base Information

Chemical Name:(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide
CAS No.:857041-03-3
Molecular Formula:C₂₆H₃₆ClN₃O₅
Molecular Weight:506.042
Hs Code.:

Synonyms:(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Suppliers and Price of (2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

There total 5 articles about (2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 866552-89-8
{2-(4-tert-butoxy-phenyl)-1-[(2-chloro-3-nitro-benzyl)-(1-hydroxymethyl-2-methyl-butyl)-carbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 857041-03-3
(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm0491492

Reference yield:

: 857040-99-4
(2S,2S)-2-(2-chloro-3-nitrobenzylamino)-3-methylpentan-1-ol

: 857041-03-3
(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / HATU; diisopropylethylamine / CH₂Cl₂ / 0.25 h / 100 °C / microwave irradiation

2: 82 percent / DBU / tetrahydrofuran / 2 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0491492

Reference yield:

: 89639-98-5
(2-chloro-3-nitrophenyl)methanol

: 857041-03-3
(2S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2-chloro-3-nitro-benzyl)-N-[(1S,2S)-(1-hydroxymethyl-2-methylbutyl)]propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - -30 °C

2: 3.29 g / NaCNBH₃; HOAc / methanol / Heating

3: 56 percent / HATU; diisopropylethylamine / CH₂Cl₂ / 0.25 h / 100 °C / microwave irradiation

4: 82 percent / DBU / tetrahydrofuran / 2 h / 20 °C

With oxalyl dichloride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1: Swern oxidation;
DOI:10.1021/jm0491492