diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

Base Information

Chemical Name:diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate
CAS No.:1369960-67-7
Molecular Formula:C₁₉H₂₈N₃O₆P
Molecular Weight:425.422
Hs Code.:

Synonyms:diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

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Chemical Property of diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

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Technology Process of diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

There total 5 articles about diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1369960-66-6
diethyl 2-[2-(benzyloxy)ethoxy]-2-[2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)]ethylphosphonate

: 1369960-67-7
diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1039/c2ob25131k

Reference yield:

: 1369960-60-0
(E)-diethyl 2-[2-(benzyloxy)ethoxy]vinylphosphonate

: 1369960-67-7
diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: iodine / dichloromethane / -30 - 20 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 5 h / 70 °C / Inert atmosphere

3: sodium methylate / methanol / 3.5 h / 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; sodium methylate; In methanol; dichloromethane; toluene;
DOI:10.1039/c2ob25131k

Reference yield:

: (+/-)-(1R,2R)-diethyl 2-[2-(benzyloxy)ethoxy]-2-[2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)]-1-iodoethylphosphonate

: 1369960-67-7
diethyl 2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[2-(benzyloxy)ethoxy]ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 5 h / 70 °C / Inert atmosphere

2: sodium methylate / methanol / 3.5 h / 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium methylate; In methanol; toluene;
DOI:10.1039/c2ob25131k