(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

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Chemical Name:(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol
CAS No.:79146-33-1
Molecular Formula:C₂₉H₃₆N₆O₅S
Molecular Weight:580.708
Hs Code.:

Synonyms:(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

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Chemical Property of (2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

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Technology Process of (2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

There total 4 articles about (2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 697217-99-5
2-(Benzyl-methyl-amino)-1-[3-(2-mercapto-ethyl)-4-methoxy-phenyl]-ethanol

: 892-48-8
5'-deoxy-5'-chloroadenosine

: 79146-33-1
(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

Guidance literature:: With sodium hydroxide; at 70 ℃; for 4h;
DOI:10.1021/jm00143a002

Reference yield:

: 79146-30-8
3-(2'-hydroxyethyl)-4-methoxy-δ-(N-methyl-N-benzylamino)acetophenone oxalate

: 79146-33-1
(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: PBr₃ / 1 h / Heating

2: NaBH₄, aq. NaOH / methanol

3: thiourea / ethanol; H₂O / Heating

4: 43 percent / 2 N NaOH / 4 h / 70 °C

With sodium hydroxide; sodium tetrahydroborate; phosphorus tribromide; thiourea; In methanol; ethanol; water;
DOI:10.1021/jm00143a002

Reference yield:

: 79146-26-2
3-(2'-bromoethyl)-4-methoxy-δ-(N-methyl-N-benzylamino)acetophenone

: 79146-33-1
(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-(2-{5-[2-(benzyl-methyl-amino)-1-hydroxy-ethyl]-2-methoxy-phenyl}-ethylsulfanylmethyl)-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄, aq. NaOH / methanol

2: thiourea / ethanol; H₂O / Heating

3: 43 percent / 2 N NaOH / 4 h / 70 °C

With sodium hydroxide; sodium tetrahydroborate; thiourea; In methanol; ethanol; water;
DOI:10.1021/jm00143a002