{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

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Chemical Name:{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester
CAS No.:95716-14-6
Molecular Formula:C₅₂H₇₃N₉O₁₀
Molecular Weight:984.206
Hs Code.:

{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Synonyms:{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

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Chemical Property of {(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

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Technology Process of {(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

There total 10 articles about {(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 95716-13-5
(S)-1-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(R)-2-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

: 95716-14-6
{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Guidance literature:: With hydrazine hydrate; In N,N-dimethyl-formamide; for 120h; Ambient temperature;
DOI:10.1246/bcsj.57.3210

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 95716-14-6
{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

2: HCl, anisole / dioxane / 0.5 h / Ambient temperature

3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

4: 85 percent / N₂H₄*H₂O / dimethylformamide / 120 h / Ambient temperature

With hydrogenchloride; hydrazine hydrate; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.57.3210

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 95716-14-6
{(S)-4-{(S)-2-[(R)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-4-[(S)-1-((S)-2-hydrazinocarbonyl-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

2: HCl, anisole / dioxane / 0.5 h / Ambient temperature

3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

4: HCl, anisole / dioxane / 0.5 h / Ambient temperature

5: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

6: HCl, anisole / dioxane / 0.5 h / Ambient temperature

7: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, (C₂H₅)3N / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

8: 85 percent / N₂H₄*H₂O / dimethylformamide / 120 h / Ambient temperature

With hydrogenchloride; hydrazine hydrate; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.57.3210