(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

Base Information

Chemical Name:(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate
CAS No.:1198746-16-5
Molecular Formula:C₁₃H₁₂BrF₃O₃
Molecular Weight:353.136
Hs Code.:

Synonyms:(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

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Chemical Property of (R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

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Technology Process of (R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

There total 3 articles about (R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 6888-79-5
4-bromo-α-methylstyrene

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1198746-16-5
(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

Guidance literature:: With 2,6-bis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazolin-2-yl]pyridine; indium(III) chloride; silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol902507x

Reference yield: 97.0%

: 6888-79-5
4-bromo-α-methylstyrene

: trifluoromethylpyruvate

: 1198746-16-5
(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

Guidance literature:: With 2,6-bis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazolin-2-yl]pyridine; indium(III) chloride; silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Ionic liquid; Molecular sieve;
DOI:10.1002/adsc.201000170

Reference yield:

: 6888-79-5
4-bromo-α-methylstyrene

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1198746-16-5
(R)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

: 1450884-60-2
(S)-methyl 4-(4-bromophenyl)-2-hydroxy-2-(trifluoromethyl)-pent-4-enoate

Guidance literature:: With (2,6-bis((S)-4-tert-butyl-1-p-tolyl-4,5-dihydro-1H-imidazol-2-yl)-phenyl)RhCl₂(H₂O); silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 16h; Overall yield = 80 %; Overall yield = 56.5 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo4014194