(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

Base Information

Chemical Name:(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole
CAS No.:1447818-68-9
Molecular Formula:C₂₉H₂₅F₉NOP
Molecular Weight:605.483
Hs Code.:

Synonyms:(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

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Chemical Property of (R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

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Technology Process of (R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

There total 4 articles about (R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₂₉H₂₅F₉NO₂P

: 1447818-68-9
(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

Guidance literature:: With diphenylsilane; at 140 ℃; for 48h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.tetlet.2015.06.039

Reference yield:

: 944836-48-0
2-bromo-5-(trifluoromethyl)-benzoyl chloride

: 1447818-68-9
(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 4.25 h / 0 - 23 °C

2.1: methanesulfonic acid / dichloromethane / 17 h / 0 - 50 °C

3.1: copper(l) iodide; N,N-dimethylethylenediamine / toluene / 0.33 h / Inert atmosphere

3.2: 20 h / 110 °C

4.1: diphenylsilane / 48 h / 140 °C / Sealed tube; Inert atmosphere

With copper(l) iodide; methanesulfonic acid; diphenylsilane; N,N-dimethylethylenediamine; triethylamine; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2015.06.039

Reference yield:

: 1401163-62-9
(R)-3-amino-2,4-dimethylpentan-2-ol hydrogen chloride

: 1447818-68-9
(R)-2-(2-(bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 4.25 h / 0 - 23 °C

2.1: methanesulfonic acid / dichloromethane / 17 h / 0 - 50 °C

3.1: copper(l) iodide; N,N-dimethylethylenediamine / toluene / 0.33 h / Inert atmosphere

3.2: 20 h / 110 °C

4.1: diphenylsilane / 48 h / 140 °C / Sealed tube; Inert atmosphere

With copper(l) iodide; methanesulfonic acid; diphenylsilane; N,N-dimethylethylenediamine; triethylamine; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2015.06.039